Suggestion about wife’s pain (6)
I believe the answer is:
twinge
'pain' is the definition.
(I know that twinge is a type of pain)
'suggestion about wife's' is the wordplay.
'suggestion' becomes 'tinge' (I've seen this before).
'about' indicates putting letters inside.
'wife' becomes 'w' (abbreviation).
'tinge' placed around 'w' is 'TWINGE'.
(Other definitions for twinge that I've seen before include "Sharp pang" , "Brief sharp pain" , "Pinch" , "Spasm" , "A small stab of pain" .)