Sweet female, in crazy sitcom, losing son (6)
I believe the answer is:
comfit
'sweet' is the definition.
(comfit is a kind of sweet)
'female in crazy sitcom losing son' is the wordplay.
'female' becomes 'f' (abbreviation).
'in' indicates putting letters inside.
'crazy' indicates an anagram.
'losing' suggests deleting specific letters.
'son' becomes 's' (genealogical abbreviation for son).
'sitcom' with 's' taken out is 'itcom'.
'itcom' anagrammed gives 'comit'.
'f' placed into 'comit' is 'COMFIT'.
(Other definitions for comfit that I've seen before include "Sweet - MFI cot (anag)" , "Candied fruit" , "Kind of sweet, nut in sugar" , "Sweet consisting of nut in sugar" .)