Swelling small yet disastrous (4)
I believe the answer is:
stye
'swelling' is the definition.
(stye is a kind of swelling)
'small yet disastrous' is the wordplay.
'small' becomes 's' (abbreviation - e.g. clothes size).
'disastrous' is an anagram indicator.
'yet' anagrammed gives 'tye'.
's'+'tye'='STYE'
(Other definitions for stye that I've seen before include "Eye sore" , "nasty spot" , "Animal pen" , "irritation to the viewer" , "Inflamed swelling on the edge of an eyelid" .)