Take no notice of foreign region (6)
I believe the answer is:
ignore
'take no notice of' is the definition.
(to take no notice of something is to ignore it)
'foreign region' is the wordplay.
'foreign' indicates an anagram (foreign order of the letters).
'region' with letters rearranged gives 'IGNORE'.
(Other definitions for ignore that I've seen before include "Turn a blind eye to" , "Forget" , "Neglect" , "Fail to observe" , "'Disregard, overlook (6)'" .)