Take up positive response about circle in London borough (8)
I believe the answer is:
haringey
'london borough' is the definition.
(I know that Haringey is a London borough)
'take up positive response about circle' is the wordplay.
'take up' shows that the letters should be reversed in order (I've seen 'taken up' mean this).
'positive response' becomes 'yeah' (I've seen this before).
'about' means one lot of letters goes inside another.
'circle' becomes 'ring' (synonyms).
'yeah' reversed gives 'haey'.
'haey' going around 'ring' is 'HARINGEY'.
'in' is the link.
(Another definition for haringey that I've seen is " Where in London".)