That man wants the heart of one female (3)
I believe the answer is:
hen
'female' is the definition.
(I've seen this before)
'that man wants the heart of one' is the wordplay.
'that man' becomes 'he' (**).
'wants' means one lot of letters go next to another.
'the heart of' indicates the central letters.
The centre of 'one' is 'n'.
'he'+'n'='HEN'
(Other definitions for hen that I've seen before include "Domestic egg layer" , "Source of eggs" , "Farm bird" , "Coop resident" , "Composed of women" .)