The crossword setter's motif (5)
I believe the answer is:
theme
'motif' is the definition.
(synonyms)
'the crossword setter's' is the wordplay.
'crossword setter' becomes 'me' (referring to the person writing the clues).
'the'+'me'='THEME'
(Other definitions for theme that I've seen before include "Topic for discussion" , "Subject (of talk, text, etc)" , "Recurring melody" , "Topic; melody" , "Thread, melody" .)