The game is to follow one's destiny (5)
I believe the answer is:
lotto
'the game' is the definition.
(the UK National Lottery)
'to follow one's destiny' is the wordplay.
I cannot quite see how this works, but
'to' is within the answer.
'destiny' could be 'lot' (I've seen this in another clue) and 'lot' is found within the answer.
This accounts for all the letters.
This explanation may well be incorrect...
'is' is the link.
Can you help me to learn more?
(Other definitions for lotto that I've seen before include "Bingo-like game" , "Game of chance based on numbered balls being drawn at random" , "Housey-housey, bingo" , "Children's game; lottery" , "Game in which numbers are drawn" .)