They give a direction in entrances (6)
I believe the answer is:
donors
'they give' is the definition.
(I've seen this in another clue)
'a direction in entrances' is the wordplay.
'a direction' becomes 'n' (N is an example).
'in' indicates putting letters inside.
'entrances' becomes 'doors' (door is a kind of entrance).
'n' inserted into 'doors' is 'DONORS'.
(Other definitions for donors that I've seen before include "presenters" , "They give, money or blood" , "They give things including blood" , "They give to others, maybe blood" , "They give, blood say" .)