They run drugs over points across river (8)
I believe the answer is:
escapers
'they run' is the definition.
I know nothing about this answer so I cannot judge whether this works.
'drugs over points across river' is the wordplay.
I cannot quite understand how this works, but
'drugs' could be 'es' (ecstasy tablets) and 'es' is found within the answer.
'river' could be 'r' (abbreviation for river) and 'r' is found in the answer.
'points' could be 'capes' (a cape is a type of geographical point) and 'capes' is located in the leftover letters.
This accounts for all the letters.
This may be the basis of clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for escapers that I've seen before include "those taking flight" , "Fugitives as from jail or captors" .)