They say you again got entangled with an American native (6)
I believe the answer is:
iguana
'an american native' is the definition.
Although both the answer and definition are singular nouns, I cannot see how they can define each other.
'they say you again got entangled' is the wordplay.
I cannot quite see how this works, but
'you' could be 'u' (commonly used in online communication) and 'u' is present in the answer.
an anagram of 'again' is 'igana' which is present in the left over letters.
This accounts for all the letters.
This explanation may well be incorrect...
'with' is the link.
Can you help me to learn more?
(Other definitions for iguana that I've seen before include "Herbivore" , "Large tree-climbing specimen of 5 down in tropical America" , "Animal" , "Large lizard found in Guiana" , "The Night of the ---, (T. Williams)" .)