They're not at home with regulations (7)
I believe the answer is:
outlaws
'they're' is the definition.
The definition suggests an adverb but the answer is not.
'not at home with regulations' is the wordplay.
'not at home' becomes 'out' (out can mean away from home).
'with' is a charade indicator (letters next to each other).
'regulations' becomes 'laws' (I've seen this before).
'out'+'laws'='OUTLAWS'
Can you help me to learn more?
(Other definitions for outlaws that I've seen before include "Criminals!" , "Bans" , "Bandits?" .)