This can treat low vitality and a persistent shaking (14)

I believe the answer is:

antidepressant

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'this can treat low vitality' is the definition.
The definition suggests a singular noun which matches the answer.

'and a persistent shaking' is the wordplay.
'shaking' indicates anagramming the letters.
'and'+'a'+'persistent'='andapersistent'
'andapersistent' is an anagram of 'ANTIDEPRESSANT'.

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(Other definitions for antidepressant that I've seen before include "Uplifting drug" , "Mood-lightening drug" .)

I've seen this clue in The Guardian.

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