Crossword Genius

Thus, again, makes one angry (4)

Ross

I believe the answer is:

sore

'one angry' is the definition.
(I've seen this in another clue)

'thus again' is the wordplay.
'thus' becomes 'so' (synonyms).
'again' becomes 're' (prefix meaning 'again').
'so'+'re'='SORE'

'makes' is the link.

(Other definitions for sore that I've seen before include "Spot of aggravation" , "To be very old" , "Irritated or painful" , "Hurting, painful" , "Raw or annoyed" .)

I've seen this clue in the Evening Standard.
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