Crossword Genius

Tied in factories with change leading to a loss of living things (15)

Ross

I believe the answer is:

desertification

'a loss of living things' is the definition.

'tied in factories with change leading' is the subsidiary indication.
'tied in factories' anagrams to 'desertification'.
However, I am not sure how the anagram is indicated.

'to' is the link.

I've seen this clue in The Times.
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