To the south, a German river! (5)
I believe the answer is:
seine
'river' is the definition.
(river in France)
'to the south a german' is the wordplay.
'to the south' becomes 's' (abbreviation).
'a german' becomes 'eine' ('a' in German).
's'+'eine'='SEINE'
(Other definitions for seine that I've seen before include "Second longest river in France" , "Paris's river" , "Paris river" , "Parisian river" , "French river -- type of fishing net" .)