Took off in small tour with heads on performance enhancing drugs (8)
I believe the answer is:
stripped
'took off' is the definition.
(stripping is a kind of taking off)
'small tour with heads on performance enhancing drugs' is the wordplay.
I cannot quite see how this works, but
'small' could be 's' (abbreviation - e.g. clothes size) and 's' is found within the answer.
'tour' could be 'trip' (I've seen this in other clues) and 'trip' is found within the answer.
'drugs' could be 'e' (somebody 'on E' could also be 'on drugs') and 'e' is found within the answer.
This explanation may well be incorrect...
'in' is the link.
Can you help me to learn more?
(Other definitions for stripped that I've seen before include "Removed paint - or clothes" , "Pets drip (anag)" , "having no gear" , "behaved 'naughtily' in club?" , "Removed clothing, perhaps forpay" .)