Toothache will involve grind (4)
I believe the answer is:
chew
'grind' is the definition.
(I know that chew is a more specific form of the action grind)
'toothache will involve' is the wordplay.
'involve' indicates the answer is hidden within the clue (I've seen 'involves' mean this).
'CHEW' is hidden in the letters of 'toothache will'.
(Other definitions for chew that I've seen before include "Work or grind between teeth" , "Munch" , "Bite and grind food in the mouth" , "Masticate, grind between teeth" , "Treat for dog" .)