Trance from taking ecstasy in a shot of whisky? (5)
I believe the answer is:
dream
'trance' is the definition.
(I've seen this before)
'ecstasy in a shot of whisky?' is the wordplay.
'ecstasy' becomes 'E' (informal term for the drug).
'in' indicates putting letters inside.
'a shot of whisky?' becomes 'dram' (I can't explain this - if you can you should give a lot more credence to this answer).
'e' placed inside 'dram' is 'DREAM'.
'from taking' acts as a link.
(Other definitions for dream that I've seen before include "Part of sleep" , "Vision - very pleasant person" , "Sleeping experience" , "Nocturnal fantasy" , "Fantastic but vain hope" .)