Trouble in Rufus Street (4)
I believe the answer is:
fuss
'trouble' is the definition.
(I know that trouble can be written as fuss)
'in rufus street' is the wordplay.
'in' indicates a hidden word.
'FUSS' is hidden in the letters of 'rufus street'.
(Other definitions for fuss that I've seen before include "Agitate" , "Excessive activity" , "Niggle" , "Worry without reason" , "Commotion - worry" .)