Troublesome Guiana reptile (6)
I believe the answer is:
iguana
'reptile' is the definition.
(iguana is a kind of reptile)
'troublesome guiana' is the wordplay.
'troublesome' indicates anagramming the letters.
'guiana' anagrammed gives 'IGUANA'.
(Other definitions for iguana that I've seen before include "Arboreal lizard of S America" , "Large tree-climbing specimen of 5 down in tropical America" , "The Night of the ---, (T. Williams)" , "Large tree-climbing lizard of tropical America" , "Animal" .)