Try second helping of this? Just starters (4)
I believe the answer is:
shot
'try' is the definition.
(both can mean an attempt)
'second helping of this? just starters' is the wordplay.
'just starters' says to take the initial letters (only the letters which start the words).
The initial letters of 'second helping of this' is 'SHOT'.
(Other definitions for shot that I've seen before include "Small drink; (rocket) launch" , "Fired - attempt" , "Small drink of liquor" , "Photo; try" , "completely gone" .)