TV series to commence again at the weekend? (4,4)
I believe the answer is:
star trek
'tv series' is the definition.
(I've seen this before)
'commence again at the weekend?' is the wordplay.
'commence' becomes 'start' (synonyms).
'again' becomes 're' (prefix meaning 'again').
'at' means one lot of letters go next to another.
'the weekend?' becomes 'k' (I've seen this in other clues).
'start'+'re'+'k'='STAR TREK'
'to' acts as a link.
(Other definitions for star trek that I've seen before include "Science fiction series" , "Kirk, Spock et al on TV" , "Enterprise?" , "Extraterrestrial journey" , "TV series" .)