Twisted! Rule again in paroxysmal pain (9)

I believe the answer is:

neuralgia

I'm a little stuck... Click here to teach me more about this clue!

'paroxysmal pain' is the definition.
'neuralgia' can be an answer for 'pain' (neuralgia is a kind of pain). I am not sure about the 'paroxysmal' bit.

'twisted rule again' is the wordplay.
'twisted' indicates anagramming the letters.
'rule'+'again'='ruleagain'
'ruleagain' with letters rearranged gives 'NEURALGIA'.

'in' acts as a link.

Can you help me to learn more?

(Other definitions for neuralgia that I've seen before include "illness" , "Severe pain through damaged nerves" , "intermittent pain" , "Pain from damaged nerve" , "Source of pain" .)

I've seen this clue in the Sydney Morning Herald.

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