Two women vacated settlement (4)
I believe the answer is:
town
'settlement' is the definition.
(I know that town is a type of municipality)
'two women vacated' is the wordplay.
'two women' can mean two substitutions for 'woman'.
'woman' becomes 'to' (I can't justify this - if you can you should give a lot more credence to this answer).
'vacated' suggests removing the centre.
'woman' with its centre taken out is 'wn'.
'to'+'wn'='TOWN'
Can you help me to learn more?
(Other definitions for town that I've seen before include "Carmathen?" , "Urban community" , "Borough" , "Won't be about population centre" , "See 1" .)