Uneasiness (7)
I believe the answer is:
malaise
'uneasiness' is the definition.
(I know that uneasiness can be written as malaise)
This is the entire clue.
(Other definitions for malaise that I've seen before include "depression" , "General feeling of unease or illness" , "Out-of-sorts feeling" , "Feeling of physical or mental illness" , "General feeling of discomfort" .)