Unlucky one guided around wrong flat (3-5)
I believe the answer is:
ill-fated
'unlucky' is the definition.
('ill-fated' can be a synonym of 'unlucky')
'one guided around wrong flat' is the subsidiary indication.
'one' becomes 'i' (roman numeral).
'guided' becomes 'led' ('lead' can be a synonym of 'guide').
'around' means one lot of letters goes inside another.
'wrong' indicates anagramming the letters.
'flat' is an anagram of 'lfat'.
'led' enclosing 'lfat' is 'llfated'.
'i'+'llfated'='illfated'
(Other definitions for ill-fated that I've seen before include "Destined to fail" , "Doomed(3.5)" , "Yelp like pig" , "Unlucky, destined to lose" , "Destined for bad luck" .)