Through having no luck, perchance (3)
I believe the answer is:
per
'through' is the definition.
('per' can mean through or by means of)
'no luck perchance' is the wordplay.
'no' indicates named letters should be taken away.
'luck' becomes 'chance' (synonyms).
'perchance' with 'chance' taken away is 'PER'.
'having' is the link.
(Other definitions for per that I've seen before include "According to" , "For each or every" , "Preposition indicating by means of" , "Preposition meaning for each" .)