Unwell and obese Edward is doomed (3-5)
I believe the answer is:
ill-fated
'is doomed' is the definition.
(thesaurus)
'unwell and obese edward' is the wordplay.
'unwell' becomes 'ill' ('ill' can be similar in meaning to 'unwell').
'and' says to put letters next to each other.
'obese' becomes 'fat' ('fat' can be similar in meaning to 'obese').
'edward' becomes 'ed'.
'ill'+'fat'+'ed'='ILL-FATED'
(Other definitions for ill-fated that I've seen before include "Unlucky, bad times ahead" , "Doomed(3.5)" , "Yelp like pig" , "Unlucky, destined to lose" , "'Doomed, unlucky (3-5)'" .)