Poorly and obese -- Edward's doomed (3-5)
I believe the answer is:
ill-fated
'doomed' is the definition.
(I've seen this before)
'poorly and obese edward's' is the wordplay.
'poorly' becomes 'ill' (synonyms).
'and' is a charade indicator (letters next to each other).
'obese' becomes 'fat' (similar in meaning).
'edward' becomes 'Ed' (short for Edward).
'ill'+'fat'+'ed'='ILL-FATED'
(Other definitions for ill-fated that I've seen before include "Destined to fail" , "Doomed(3.5)" , "Yelp like pig" , "Unlucky, destined to lose" , "Unlucky, bad times ahead" .)