Upfront, never accept the offered alliance (4)
I believe the answer is:
nato
'alliance' is the definition.
(I know that NATO is a type of global organization)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for nato that I've seen before include "Military alliance (acronym)" , "Military alliance, formed 1949" , "Atlantic alliance (abbr.)" , "Security agreement" , "Military bloc" .)