Uplifting stuff, brandy (4)
I believe the answer is:
marc
'brandy' is the definition.
(I know that marc is a type of brandy)
'uplifting stuff' is the wordplay.
'uplifting' says the letters should be written backwards.
'stuff' becomes 'cram' (synonyms).
'cram' back-to-front is 'MARC'.
(Other definitions for marc that I've seen before include "Chagall for one" , "A brandy; --- Chagall, artist" , "Fruit refuse" , "Type of eau-de-vie made from residue of grapes" , "Spirit" .)