Uproar surrounding extremely large Spanish city (6)
I believe the answer is:
toledo
'spanish city' is the definition.
(city in Spain)
'uproar surrounding extremely large' is the wordplay.
'uproar' becomes 'todo' (to-do can mean a fuss or furore).
'surrounding' means one lot of letters goes inside another.
'extremely' suggests removing the centre (only the extremes of the word are used).
'large' with its middle taken out is 'le'.
'todo' going around 'le' is 'TOLEDO'.
(Other definitions for toledo that I've seen before include "Span. sword-making city" , "Blade" , "Spanish city known for swordmaking" , "Spanish city noted for swords" , "Covering, hiding" .)