Use River Don (4)
I believe the answer is:
wear
I believe this clue is a triple definition!
'use' is the first definition.
(I've seen this in another clue)
'river' is the second definition.
(river in the north east of England)
'don' is the third definition.
(synonyms)
(Other definitions for wear that I've seen before include "Become tiresome" , "Tire; dress in" , "Accept" , "Durham's river - erosion" , "Be clothed in" .)