Verdi aria from noble Amelia mad about Carlos, perhaps (2,5,1,6)
I believe the answer is:
la donna e mobile
'verdi aria' is the definition.
(aria from the opera Rigoletto by Giuseppe Verdi)
'noble amelia mad about carlos perhaps' is the wordplay.
'mad' is an anagram indicator.
'about' is an insertion indicator.
'carlos perhaps' becomes 'don' (Verdi opera Don Carlos).
'noble'+'amelia'='nobleamelia'
'nobleamelia' anagrammed gives 'lanaemobile'.
'lanaemobile' going around 'don' is 'LA DONNA E MOBILE'.
'from' is the link.
(Other definitions for la donna e mobile that I've seen before include "operatic piece" , "Woman so fickle" , "number" , "song" , "Theme of inconstancy" .)