Very sad end for establishment with smoke rising (6)
I believe the answer is:
tragic
'very sad' is the definition.
(I've seen this before)
'end for establishment with smoke rising' is the wordplay.
'end for' indicates one should take the final letters.
'with' means one lot of letters go next to another.
'smoke' becomes 'cigar' (smoke can mean a cigar).
'rising' says the letters should be written in reverse (going up in a down clue).
The final letter of 'establishment' is 't'.
'cigar' backwards is 'ragic'.
't'+'ragic'='TRAGIC'
(Other definitions for tragic that I've seen before include "Unfortunate" , "Calamitous, very sad" , "Dire" , "Extremely sad and distressing" , "Greatly distressing" .)