Virginia houses some titled uncle (5)
I believe the answer is:
vanya
'titled uncle' is the definition.
(title character in Chekhov's Uncle Vanya)
'virginia houses some' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'houses' is an insertion indicator.
'some' becomes 'any' (similar in meaning).
'va' placed around 'any' is 'VANYA'.
(Other definitions for vanya that I've seen before include "'Uncle --', work of 19" , "Uncle making dramatic appearance" , "Uncle - - (Chekhov)" .)