Wanderer heading west loaded with Eastern spirit (6)
I believe the answer is:
daemon
'spirit' is the definition.
(I know that daemon is a type of evil spirit)
'wanderer heading west loaded with eastern' is the wordplay.
'wanderer' becomes 'nomad' (nomad is a kind of wanderer).
'heading west' shows that the letters should be reversed in order.
'loaded with' indicates putting letters inside.
'eastern' becomes 'e'.
'nomad' reversed gives 'damon'.
'damon' placed around 'e' is 'DAEMON'.
(Other definitions for daemon that I've seen before include "Evil spirit" , "guardian spirit" , "Spirit in ancient Greek belief" .)