What hindered you initially, and for what reason? (3)
I believe the answer is:
why
'for what reason?' is the definition.
(I've seen this in another clue)
'what hindered you initially' is the wordplay.
'initially' suggests taking the first letters.
The first letters of 'what hindered you' is 'WHY'.
'and' acts as a link.
(Other definitions for why that I've seen before include "For what reason?" , "How come?" , "Question" .)