When upset, concerning male might whine (6)
I believe the answer is:
yammer
'whine' is the definition.
(I know that whine can be written as yammer)
'when upset concerning male might' is the wordplay.
'when upset' shows that the letters should be reversed in order (in a down clue - set, written, up).
'concerning' becomes 're' (both can mean on a particular topic).
'male' becomes 'm' (common abbreviation).
'might' becomes 'may' (I've seen this in another clue).
're'+'m'+'may'='remmay'
'remmay' reversed gives 'YAMMER'.
(Other definitions for yammer that I've seen before include "complaint" , "Complain persistently or jabber" , "Talk loudly at length" , "Wail" , "Talk loudly and incessantly" .)