Wipe out resistance in comfort (5)
I believe the answer is:
erase
'wipe' is the definition.
(I've seen this in another clue)
'resistance in comfort' is the wordplay.
'resistance' becomes 'r' (abbreviation in physics and electronics).
'in' is an insertion indicator.
'comfort' becomes 'ease' (synonyms).
'r' placed into 'ease' is 'ERASE'.
'out' is the link.
(Other definitions for erase that I've seen before include "To remove all trace" , "Delete" , "Take out" , "Efface" , "Remove, wipe out" .)