With leader gone, political and social agitation is an issue (7)
I believe the answer is:
edition
'an issue' is the definition.
(edition is a kind of issue)
'with leader gone political and social agitation' is the wordplay.
'with leader gone' means to remove the first letter.
'political and social agitation' becomes 'sedition'.
'sedition' with its first letter removed is 'EDITION'.
'is' acts as a link.
(Other definitions for edition that I've seen before include "Particular form of a published text" , "One version of a published text" , "Particular form of a book" , "Particular version of a published text" , "Total numbers issued at one time, say of book" .)