With liver trouble, a female (6)
I believe the answer is:
elvira
'female' is the definition.
I don't know anything about this answer so I cannot judge whether it can be defined by this definition.
'with liver trouble a' is the wordplay.
'with' says to put letters next to each other.
'trouble' is an anagram indicator.
'liver' with letters rearranged gives 'elvir'.
'elvir' put next to 'a' is 'ELVIRA'.
Can you help me to learn more?
(Other definitions for elvira that I've seen before include "Girl's name (from Don Giovanni)" , "Coward spirit" .)