With no goals, direct girl to sub American for European (7)
I believe the answer is:
aimless
'with no goals' is the definition.
I don't understand how the remainder of the clue works.
(Other definitions for aimless that I've seen before include "Melissa (anag) -- unmotivated" , "Like characters in 5D {WAITING FOR GODOT]" , "Drifting - Melissa (anag)" , "Lacking purpose" , "Rambling" .)