Work a lot with new nail (5)
I believe the answer is:
talon
'nail' is the definition.
(thesaurus)
'work a lot with new' is the wordplay.
'work' indicates anagramming the letters.
'with' is a charade indicator (letters next to each other).
'new' becomes 'n' (common abbreviation eg NT for New Testament).
'a'+'lot'='alot'
'alot' with letters rearranged gives 'talo'.
'talo'+'n'='TALON'
(Other definitions for talon that I've seen before include "Holding part of flier" , "part to make savage cuts" , "hunting hook" , "Raptor's claw" , "E.g. hawk's claw" .)