Wreck, destroy (4)
I believe the answer is:
ruin
I believe this clue is a double definition.
'wreck' is the first definition.
(I know that wreck is a more specific form of ruin)
'destroy' is the second definition.
(I know that ruin is a more specific form of desolate)
(Other definitions for ruin that I've seen before include "Destroy; downfall" , "Physical collapse" , "state of collapse" , "Scotch" , "Spoil, impoverish" .)