Yearning without profit after drug high? Or checking out? (5,2)

'yearning without profit after drug' is the definition.
I know nothing about this answer so I cannot tell whether this works.

'high? or checking out?' is the wordplay.
I cannot quite understand how this works, but
'high?' could be 'up' (associated in meaning) and 'up' is found in the answer.
'checking out?' could be 'eying' (I've seen this in another clue) and 'eying' is found within the answer.
This accounts for all the letters.
This may be the basis of the clue (or it may be nonsense).

Can you help me to learn more?