Best ran generally around getting divorce (8)
I believe the answer is:
estrange
'divorce' is the definition.
(I've seen this before)
'best ran generally around' is the wordplay.
'around' indicates the answer is hidden within the clue.
'ESTRANGE' can be found hidden inside 'best ran generally'.
'getting' is the link.
(Other definitions for estrange that I've seen before include "Drive away" , "Anger set (anag.)" , "Cause to become unfriendly using reagents" , "Alienate from friendship" , "Alien" .)