Bird and guano flew off without one (6,4)
I believe the answer is:
guinea fowl
'bird' is the definition.
(guinea fowl is a kind of bird)
'guano flew off without one' is the wordplay.
'off' is an anagram indicator.
'without' indicates putting letters inside ('without' can be similar in meaning to 'outside').
'one' becomes 'i' (Roman numeral).
'guano'+'flew'='guanoflew'
'guanoflew' with letters rearranged gives 'guneafowl'.
'guneafowl' enclosing 'i' is 'GUINEA-FOWL'.
'and' acts as a link.
(Other definitions for guinea fowl that I've seen before include "African game bird" , "African bird related to the pheasant" .)