Create difficulty for philosopher endlessly cut by left (6)
I believe the answer is:
hobble
'create difficulty for' is the definition.
'philosopher endlessly cut by left' is the wordplay.
'philosopher' becomes 'hobbes' (Thomas Hobbes).
'endlessly' means to remove the last letter.
'cut by' means one lot of letters goes inside another.
'left' becomes 'l' (common abbreviation).
'hobbes' with its last letter taken off is 'hobbe'.
'hobbe' going around 'l' is 'HOBBLE'.
(Other definitions for hobble that I've seen before include "Confusion of languages" , "Walk lamely or use rope to restrict horse" , "Walk lamely or tie horse" , "Make lame" , "Walk with difficulty" .)